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Bioinformatics methods for protein identification using peptide mass fingerprinting data
(University of Missouri--Columbia, 2009)
Protein identification using mass spectrometry is an important yet partially solved problem in the study of proteomics during the post-genomic era. The major techniques used in mass spectrometry are Peptide Mass Fingerprinting (PMF) and Tandem mass...
Development of a multi-omics approach to identify highly correlated transcriptomic, proteomic and metabolic signatures in maize B73 and FR697 drought stressed nodal roots
(University of Missouri--Columbia, 2021)
, we analyzed multiomics (transcriptome, proteome, metabolome) datasets generated from the growth zone of nodal roots collected from the reference inbred line B73 and from inbred line FR697, which exhibits a relatively greater ability to maintain root...
Drug resistance in D. discoideum: isolation of 4-nitroquinoline 1-oxide resistant mutants
(University of Missouri--Columbia, 2005)
The drug 4-nitroquinoline 1-oxide (4NQO) displays both carcinogenic and antitumor effects, a well known characteristic of many chemotherapeutic drugs. In addition 4NQO shares a similar operating mechanism with the commonly ...
Low-intensity blast-induced mild traumatic brain injury : linking blast physics to biological outcomes
(University of Missouri--Columbia, 2019)
of 350 g of high-energy explosive C4. The use of an open-field experimental blast generated a primary blast wave with a peak overpressure of 6.76 pounds per square inch (PSI) (46.6 kPa) at a 3-meter (m) distance from the center of the explosion...
Uncovering the genetic basis of seed amino acid composition in arabidopsis using a multi-omics integrative approach
(University of Missouri--Columbia, 2021)
to create a seed with a more balanced amino acid profile. However, upon perturbations to the proteome, mutant seeds have demonstrated a rebalancing phenomenon where even large alterations to the amino acid composition activate a compensation mechanism...
A custom oligonucleotide microarray analysis as a tool for dissecting soybean-bradyrhizobium japonicum nodule senescence
(University of Missouri--Columbia, 2007)
connecting the bacteroids. This study demonstrates how global analysis can lead to new and novel discoveries.--From public.pdf....
Protein transport : bioinformatics methods for understanding protein subcellular localization
(University of Missouri--Columbia, 2018)
an efficient and effective way for studying the protein subcellular localization on the whole-proteome level. Here, we present in this dissertation the bioinformatics methods for studying protein subcellular localization. We reviewed the studies of protein...
Discovery and phenotyping of the determinants and receptors of post-fertilization sperm mitophagy
(University of Missouri--Columbia, 2023)
fertilization. In the context of fertilization events, a multi-pronged proteomic and sperm phenotyping approach is used to further understand the function and distribution of 185 candidate sperm mitophagy substrates and determinants identified by proteomic...
The identification of a diagnostic biomarker panel for canine osteoarthritis
(University of Missouri--Columbia, 2010)
individuals. In vitro studies in the hip suggested the articular cartilage and subchondral bone were at least partially accountable for these fluctuations. Proteomics methods were utilized to investigate differences in protein profiles from the culture studies...
An interpretable protein localization prediction framework
(University of Missouri--Columbia, 2021)
at https://www.mu-loc.org/....
Reflux, aspiration and respiratory disease in dogs : clinical consideration and advances in aerodigestive diagnostics
(University of Missouri--Columbia, 2019)
The aspiration of gastric contents into the respiratory tract has been associated with the development and progression of multiple respiratory diseases in humans. In veterinary medicine the term "aspiration" is considered ...
Uncovering the genetic architecture and metabolic basis of amino acid composition in maize kernels using multi-omics integration
(University of Missouri--Columbia, 2020)
are met. Many attempts to increase the EAA has demonstrated only limited success since seed can rebalance their amino acids composition even when major changes are introduced in their proteome. One possible approach to solve this applied problem is by seed...
Investigation of the initial steps of jasmonic acid biosynthesis and a study of differential regulation of the ribosomal association of mRNA transcripts in jasmonate-dependent wound response
(University of Missouri--Columbia, 2020)
into both the common and unique aspects of the regulation of JA biosynthetic pathway in N. benthamiana. In chapter III the wound induced post-transcriptional regulation of mRNAs were studied by utilizing transcriptomic, proteomic, and translatomic approaches...
Roles of clathrin-coated vesicle networks in plant immunity and development
(University of Missouri--Columbia, 2018)
multiple putative null mutant alleles either from UniformMu stocks or through Ds mobilization and proceeded to introgress these mutant lines into the genetically uniform B73 reference genome. Genetic tools generated here will allow us to assess organismal...
Roles of dynamin-related protein network in plant immune responses and development
(University of Missouri--Columbia, 2020)
, the intracellular molecular machinery that modulates the PM proteome for signal initiation and attenuation of responses to biotic stimuli remains mostly undefined. PM localized pattern recognition receptors (PRRs) are capable of recognizing their cognate ligands...
Understanding the role of Coxiella outer membrane protein-1 in relation to the Type IVB Secretion system of Coxiella burnetii
(University of Missouri--Columbia, 2022)
Obligate intracellular bacterial pathogens, like Coxiella burnetii, the causative agent of Q Fever, rely upon the host for metabolites and carbon sources for energy and biosynthesis of nucleic acids, proteins, and energy ...
Investigating the long-term effects of non-inertial low-intensity blast-induced mild traumatic brain injury in mice
(University of Missouri--Columbia, 2023)
risk of neurological consequences that persist long after injury pose significant public health burdens. However, the contribution of LIB-induced mTBI causing these long-term neurological outcomes and their underlying mechanism(s) are incompletely...
The role of TRAF3IP2 in obesity-associated vascular insulin resistance and dysfunction
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] Insulin resistance in the vasculature is a characteristic feature of obesity and contributes to the pathogenesis of vascular dysfunction and ...
Extracellular vesicles : novel mediators of conceptus-maternal interactions in sheep
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Infertility and pregnancy loss are common problems affecting reproductive efficiency, health and development in livestock. Pregnancy loss occurs most ...
Uterine regulation of preimplantation embryo development in fertility-classified heifers
(University of Missouri--Columbia, 2018)
Infertility and subfertility represent pervasive problems in domestic animals and humans, and embryonic mortality is a major factor influencing reproductive efficiency. In cattle, the majority of embryonic loss occurs ...